反应详情

Into a 100 mL round bottom flask was placed 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)benzenamine (2.05 g, 8 mmol) and EtOH (40 mL). Flask sparged with argon, then 10% Palladium on carbon (100 mg) is added. Argon removed and replaced with hydrogen via balloon, stirs overnight at RT. Work up: Filtered reaction mixture through Celite® under inert atmosphere. Removed solvents under reduced pressure. Purified via silica column using 0 to 100% 90/10/1 (DCM/MeOH/NH4OH) gradient in DCM. Affords a pale yellow oil. LC-MS(+) shows mass 259 (M+H), as expected for C13H17F3N2, mw 258.28.

1. customInto a 100 mL round bottom flask was placed
2. customFlask sparged with argon
3. addition10% Palladium on carbon (100 mg) is added
4. customArgon removed
5. customreplaced with hydrogen via balloon, stirs overnight at RT
6. filtrationFiltered
7. customreaction mixture through Celite® under inert atmosphere
8. customPurified via silica column
9. customAffords a pale yellow oil