Thionyl Chloride → 4-Methoxy-3-nitrobenzoyl chloride

HRID 2115892Notes

Reaction equation

HRID 2115892 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[N+:12]([O-:14])=[O:13].S(Cl)([Cl:17])=O>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:17])=[O:8])=[CH:5][C:4]=1[N+:12]([O-:14])=[O:13]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 666404-Methoxy-3-nitrobenzoic acid

Product 1

HCID 123754634-Methoxy-3-nitrobenzoyl chloride

Procedure

4-methoxy-3-nitrobenzoic acid (10.0 g, 0.051 mol), and thionyl chloride (25 g, 0.212 mol), were refluxed together for 24 h. The reaction mixture was cooled to RT and concentrated to dryness. The off-white solid was carried onto the next step.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-08fa15a63bd94db1a2cd6cfc3243b6fe
Source dataset
uspto-grants-2008_10
Patent number
US07435823B2

Reaction notes

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