Triethylamine → HCID 86628264, compound

Participants

Reaction Steps

In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0316 g, 0.0685 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0540 mL, 0.390 mmol) and 1,3,5-trimethyl-1H-pyrazol-4-sulfonyl chloride (0.0407 g, 0.195 mmol) to obtain 4-(1,3,5-trimethyl-1H-pyrazol-4-ylsulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0118 g, yield 27%).

Provenance & Evidence