2,5-Dichlorobenzeneboronic acid → HCID 86599165, compound

HRID 2116085Notes

Reaction equation

HRID 2116085 reaction equation
Br[C:2]1[C:10]2[O:9][CH:8]([CH2:11][NH:12][C:13](=[O:15])[O-:14])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=1B(O)O>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=1[C:2]1[C:10]2[O:9][CH:8]([CH2:11][NH:12][C:13](=[O:15])[O:14][CH2:7][C:6]3[CH:10]=[CH:2][CH:3]=[CH:4][CH:5]=3)[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27733712,5-Dichlorobenzeneboronic acidHCID 86599166HCID 86599166, compound

Product 1

HCID 86599165HCID 86599165, compoundYield 27%

Procedure

Treatment of (±)-(7-bromo-2,3-dihydro-benzofuran-2-ylmethyl)carbamate (3.2 g, 8.83 mmol) with 2,5-dichlorophenylboronic acid (2.54 g, 13.24 mmol) generally according to the procedure described for Intermediate 37 provided 0.299 g (27%) of (±)-benzyl {[7-(2,5-dichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl}carbamate as a yellow oil.

Sources & evidence

ORD record
ord-3b26f6a321f4408391f173313cacee87
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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