Hydrochloric Acid → HCID 16655411, compound

Participants

Reaction Steps

To a solution of (1S)-2-bromo-1-(5-fluoro-2-hydroxybenzyl)ethyl acetate (3.57 g, 12.2 mmol) in methanol was added hydrogen chloride (1.0 M in diethylether, 49 ml) and the reaction mixture was allowed to stir at room temperature for 12 h. The solvent was removed in vacuo and purification by flash column chromatography (silica, ethyl acetate:hexanes 3:7) afforded 2.95 g (97%) of (S)-2-(3-bromo-2-hydroxy-propyl)-4-fluoro-phenol as a colorless oil. HRMS ESI m/e 246.9761 [M−H]+; Calc'd 246.9755. [α]D25=+8.2° (c 0.71% in methanol).

Provenance & Evidence