Triphenylphosphine → HCID 16655467, compound

Participants

Reaction Steps

Treatment of (S)-2-(3-bromo-2-hydroxy-propyl)4-fluoro-phenol (1.97 g, 8 mmol), triphenylphosphine (5.2 g, 20 mmol), and diethylazodicarboxylate (3.11 ml, 20 mmol) generally according to the procedure described for Intermediate 18 afforded 1.40 g (76%) of (R)-2-bromomethyl-5-fluoro-2,3-dihydro-benzofuran as a colorless oil. HRMS ESI m/e 228.9661 [M−H]−. [α]D25=−33.0 (c 1% in methanol).

Provenance & Evidence