HCID 86599133, compound → HCID 11960770, compound

Participants

Reaction Steps

Treatment of (+)-benzyl {[7-(3-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl}carbamate (0.326 g, 0.864 mmol) with palladium on carbon (0.033 g, 10 wt. %) generally according to the procedure described for Example 1 provided 0.195 g (81%) of (+)-1-[7-(3-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methanamine as a white solid, hydrochloride salt. [α]D25=+18.32 (c 10.0 in methanol); mp 186-188° C.; Anal. calcd. for C15H14FNOHCl: C, 64.4; H, 5.4; N, 5.01. Found: C, 63.32; H, 5.1; N, 4.86.

Provenance & Evidence