Trimethylsilyl iodide → HCID 11960868, compound

Participants

Reaction Steps

Treatment of (−)-benzyl {[7-(2,4-dichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl}carbamate (1.85 g, 4.32 mmol) with iodotrimethylsilane (3.45 g, 17.28 mmol) generally according to the procedure described for Example 129 gave 1.04 g (82%) of (+)-1-[7-(2,4-dichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methanamine as a white solid, hydrochloride salt. [α]D25=+2.7 (c 10.0 in dimethylsulfoxide); mp 201-204° C.; Anal. calcd. for C15H13Cl2NOHCl: C, 54.59; H, 4.27; N, 4.24. Found: C, 54.25; H, 4.12; N, 4.16.

Provenance & Evidence