Cyclopropanemethanamine → HCID 15942598, compound

HRID 2116221Notes

Reaction equation

CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([F:30])[CH:20]=[C:21]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=4[Cl:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[NH2:31][CH2:32][CH:33]1[CH2:35][CH2:34]1>>[CH:33]1([CH2:32][NH:31][CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([F:30])[CH:20]=[C:21]([C:22]4[C:23]([Cl:29])=[CH:24][CH:25]=[CH:26][C:27]=4[Cl:28])[C:15]=3[O:14]2)[CH2:35][CH2:34]1

Participants

Reactant 2

HCID 75646Cyclopropanemethanamine

HCID 86599254HCID 86599254, compound

Product 1

HCID 15942598HCID 15942598, compound

Procedure

The title compound was prepared (0.066 g, 54%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-([5-fluoro-7-(2,6-dichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.14 g, 0.30 mmol) and (aminomethyl)cyclopropane (0.21 g, 3.0 mmol). mp 130-133° C.

Sources & evidence

ORD record: ord-fd5660750f134dd8b3acd637bc31fd45
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07435837B2

Reaction notes

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