Ethylamine → HCID 11450650, compound

HRID 2116223Notes

Reaction equation

HRID 2116223 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([F:30])[CH:20]=[C:21]([C:22]4[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=4[Cl:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH2:31]([NH2:33])[CH3:32]>>[Cl:29][C:23]1[CH:24]=[CH:25][CH:26]=[C:27]([Cl:28])[C:22]=1[C:21]1[C:15]2[O:14][CH:13]([CH2:12][NH:33][CH2:31][CH3:32])[CH2:17][C:16]=2[CH:18]=[C:19]([F:30])[CH:20]=1

Participants

3

Reactant 2

HCID 6341EthylamineHCID 86599254HCID 86599254, compound

Product 1

HCID 11450650HCID 11450650, compound

Procedure

The title compound was prepared (0.068 g, 56%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-([5-fluoro-7-(2,6-dichlorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.15 g, 0.32 mmol) and ethylamine (0.138 g, 3.2 mmol). mp 138.140° C.

Sources & evidence

ORD record
ord-dfcffc64dddc4e49a1e3da2fb0f914f1
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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