Cyclopropanemethanamine → HCID 15941517, compound

HRID 2116230Notes

Reaction equation

HRID 2116230 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([Cl:30])[CH:20]=[C:21]([C:22]4[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:23]=4[CH3:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[NH2:31][CH2:32][CH:33]1[CH2:35][CH2:34]1>>[Cl:30][C:19]1[CH:20]=[C:21]([C:22]2[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:29])[C:15]2[O:14][CH:13]([CH2:12][NH:31][CH2:32][CH:33]3[CH2:35][CH2:34]3)[CH2:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 86599257HCID 86599257, compound

Product 1

HCID 15941517HCID 15941517, compound

Procedure

The title compound was prepared (0.058 g, 45%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-([5-chloro-7-(2,6-dimethylphenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.15 g, 0.338 mmol) and (aminomethyl)cyclopropane (0.50 g, 6.77 mmol). mp 203-205° C.

Sources & evidence

ORD record
ord-11d9fefc91a840dea3a0daba701b597a
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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