2-Methylphenyl boronic acid → HCID 68966030, compound

HRID 2116297Notes

Reaction equation

HRID 2116297 reaction equation
Br[C:2]1[C:10]2[O:9][CH:8]([CH2:11][NH:12][CH3:13])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1B(O)O>>[CH3:13][NH:12][CH2:11][CH:8]1[CH2:7][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[CH3:14])[C:10]=2[O:9]1

Participants

3

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 68962385HCID 68962385, compound

Product 1

HCID 68966030HCID 68966030, compound

Procedure

The title compound was prepared (0.055 g, 24%) following the general procedure of Example 154 as a white solid, hydrochloride salt from (±)-[(7-bromo-2,3-dihydro-1-benzofuran-2-yl)methyl]methylamine (0.20 g, 0.826 mmol) and 2-methylphenylboronic acid (0.168 g, 1.24 mmol). mp 166-169° C.

Sources & evidence

ORD record
ord-c812557a198248d1948188ec6d05853c
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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