2-Chlorophenylboronic acid → HCID 68964025, compound

HRID 2116298Notes

Reaction equation

HRID 2116298 reaction equation
Br[C:2]1[C:10]2[O:9][CH:8]([CH2:11][NH:12][CH3:13])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1B(O)O>>[CH3:13][NH:12][CH2:11][CH:8]1[CH2:7][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[Cl:14])[C:10]=2[O:9]1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 68962385HCID 68962385, compound

Product 1

HCID 68964025HCID 68964025, compound

Procedure

The title compound was prepared (0.078 g, 40%) following the general procedure of Example 154 as a white solid, hydrochloride salt from (±)-[(7-bromo-2,3-dihydro-1-benzofuran-2-yl)methyl]methylamine (0.20 g, 0.826 mmol) and 2-chlorophenylboronic acid (0.194 g, 1.24 mmol). mp 163-165° C.

Sources & evidence

ORD record
ord-69348ef23ea043409b9cb73c8cd56dd0
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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