3-Fluorophenylboronic acid → HCID 11964049, compound

HRID 2116302Notes

Reaction equation

HRID 2116302 reaction equation
Br[C:2]1[C:10]2[O:9][CH:8]([CH2:11][NH:12][CH3:13])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[F:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[CH3:13][NH:12][CH2:11][CH:8]1[CH2:7][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([F:14])[CH:20]=3)[C:10]=2[O:9]1

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 68962385HCID 68962385, compound

Product 1

HCID 11964049HCID 11964049, compound

Procedure

The title compound was prepared (0.38 g, 53%) following the general procedure of Example 154 as a white solid, hydrochloride salt from (±)-[(7-bromo-2,3-dihydro-1-benzofuran-2-yl)methyl]methylamine (0.200 g, 0.826 mmol) and 3-fluorophenylboronic acid (0.173 g, 1.24 mmol). mp 160-163° C.

Sources & evidence

ORD record
ord-f4b55f0def434c91aeb6a59424e63713
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

Loading…