(3-Methoxyphenyl)boronic acid → HCID 11964051, compound

HRID 2116304Notes

Reaction equation

HRID 2116304 reaction equation
Br[C:2]1[C:10]2[O:9][CH:8]([CH2:11][NH:12][CH3:13])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1>>[CH3:13][NH:12][CH2:11][CH:8]1[CH2:7][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([O:15][CH3:14])[CH:21]=3)[C:10]=2[O:9]1

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 68962385HCID 68962385, compound

Product 1

HCID 11964051HCID 11964051, compound

Procedure

The title compound was prepared (0.41 g, 49%) following the general procedure of Example 154 as a white solid, hydrochloride salt from (±)-[(7-bromo-2,3-dihydro-1-benzofuran-2-yl)methyl]methylamine (0.200 g, 0.826 mmol) and 3-methoxyphenylboronic acid (0.188 g, 1.24 mmol). mp 148-151° C.

Sources & evidence

ORD record
ord-32312f40a77544afb76415bd380cc5c4
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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