4-Fluorophenylboronic acid → HCID 69108469, compound

HRID 2116306Notes

Reaction equation

HRID 2116306 reaction equation
Br[C:2]1[C:10]2[O:9][CH:8]([CH2:11][NH:12][CH3:13])[CH2:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[CH3:13][NH:12][CH2:11][CH:8]1[CH2:7][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([C:18]3[CH:19]=[CH:20][C:15]([F:14])=[CH:16][CH:17]=3)[C:10]=2[O:9]1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 68962385HCID 68962385, compound

Product 1

HCID 69108469HCID 69108469, compound

Procedure

The title compound was prepared (0.049 g, 21%) following the general procedure of Example 154 as a white solid, hydrochloride salt from (±)-[(7-bromo-2,3-dihydro-1-benzofuran-2-yl)methyl]methylamine (0.200 g, 0.826 mmol) and 4-fluorophenylboronic acid (0.173 g, 1.24 mmol). mp 209-211° C.

Sources & evidence

ORD record
ord-790ec306d35d484d8f2e1f70327a56d9
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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