HCID 68805672, compound → HCID 10472227, compound

HRID 2116473Notes

Reaction equation

HRID 2116473 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)(=[O:22])=[O:21])[CH:17]=[CH:16][C:15]=2[Cl:29])[CH2:10][CH2:9]1)=O)(C)(C)C>O1CCOCC1>[C:23]1([S:20]([C:18]2[CH:17]=[CH:16][C:15]([Cl:29])=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=2)(=[O:22])=[O:21])[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 1

HCID 68805672HCID 68805672, compound

Product 1

HCID 10472227HCID 10472227, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

4-(5-Phenylsulfonyl-2-chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester (D4B) was dissolved in 8 ml of 1,4-dioxane/4 M HCl 1:1. The mixture was heated at 60° C. for 1 h. The solvent was evaporated in vacuo to give the title product as a colourless solid.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-164b300854a24ad183d77f2485f30d7f
Source dataset
uspto-grants-2008_10
Patent number
US07439245B2

Reaction notes

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