tert-Butyl piperazine-1-carboxylate → HCID 69197380, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of 8-chloro-3-[(3-chlorophenyl)methyl]quinoline (D3)(0.25 g, 0.87 mmol), 1,1-dimethylethyl 1-piperazinecarboxylate (0.228 g, 1.2 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.025 g, 0.027 mmol), 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl (0.03 g, 0.076 mmol) and sodium tert-butoxide (0.118 g, 1.23 mmol) in degassed 1,4-dioxan (3.8 ml) under argon was heated at 80° C. under argon of 18 h. The cooled reaction mixture was diluted with dichloromethane (50 ml) and washed with water (50 ml), dried (MgSO4) and concentrated in vacuo to an oil. The oil was purified by chromatography over silica gel eluting with a gradient of acetone/toluene to give the title compound (D4) as an oil (0.202 g, 0.46 mmol, 53%).

Provenance & Evidence