Benzene, 1-fluoro-2-methyl-4-nitro- → HCID 22993871, compound

HRID 2116553Notes

Reaction equation

HRID 2116553 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([OH:19])[CH:18]=1>>[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([O:19][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[CH3:11])[CH:18]=1

Participants

3

Reactant 2

HCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 5823053-Hydroxy-5-chloropyridine

Product 1

HCID 22993871HCID 22993871, compoundYield 81.9%

Procedure

2-Fluoro-5-nitrotoluene (5.08 g) and 3-chloro-5-hydroxypyridine (4.25 g) were combined at 80° C. using a method similar to that of Example 21.2 to provide 7.1 g of 2-(3-chloro-5-pyridyloxy)-5-nitrotoluene. mp 80-82° C.

Workup

  1. customwere combined at 80° C.

Sources & evidence

ORD record
ord-325bfb101c714079b33ebfe51de1b20d
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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