4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 22993879, compound

HRID 2116562Notes

Reaction equation

HRID 2116562 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=2[NH2:19])[CH:7]=1.[F:20][C:21]([F:33])([F:32])[C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1>CCOCC>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][C:10]=2[NH:19][S:28]([C:25]2[CH:24]=[CH:23][C:22]([C:21]([F:20])([F:32])[F:33])=[CH:27][CH:26]=2)(=[O:30])=[O:29])[CH:7]=1

Participants

4

Reactant 2

HCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 22993850HCID 22993850, compound

Product 1

HCID 22993879HCID 22993879, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using the method of Example 17.4, 4-(3-chloro-5-pyridyloxy)-3-aminobenzotrifluoride (0.4 g) and 4-trifluoromethylbenzenesulfonyl chloride ((0.339 g ) were combined to provide, after trituration with ether, the title sulfonamide (0.198 g) which was obtained as a crystalline solid. mp 169-171° C.

Workup

  1. customto provide

Sources & evidence

ORD record
ord-6d8bd1cff4134b87a4c6f6a73a37bfe3
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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