4-Iodobenzenesulfonyl chloride → HCID 22993885, compound

HRID 2116565Notes

Reaction equation

HRID 2116565 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=2[NH2:19])[CH:7]=1.[I:20][C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][C:10]=2[NH:19][S:27]([C:24]2[CH:25]=[CH:26][C:21]([I:20])=[CH:22][CH:23]=2)(=[O:29])=[O:28])[CH:7]=1

Participants

3

Reactant 2

HCID 73994-Iodobenzenesulfonyl chlorideHCID 22993850HCID 22993850, compound

Product 1

HCID 22993885HCID 22993885, compoundYield 61.8%

Procedure

Using the method of Example 17.4, 4-(3-chloro-5-pyridyloxy)-3-aminobenzotrifluoride (0.41 g) and 4-iodobenzenesulfonyl chloride (0.30 g) were combined to provide the title compound (0.34 g) as crystals directly from the reaction mixture. mp 192-193° C.

Sources & evidence

ORD record
ord-e754e5dbeed94e49b653e21f730abc96
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

Loading…