Benzenesulfonyl chloride, 2,4-dichloro- → HCID 22993886, compound

HRID 2116567Notes

Reaction equation

HRID 2116567 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[C:16]([F:19])([F:18])[F:17])[CH:7]=1.[Cl:20][C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=1[S:28](Cl)(=[O:30])=[O:29]>CCCCCC.CCOCC>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][S:28]([C:22]3[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:21]=3[Cl:20])(=[O:30])=[O:29])=[CH:11][C:10]=2[C:16]([F:17])([F:19])[F:18])[CH:7]=1

Participants

4

Reactant 2

HCID 204419Benzenesulfonyl chloride, 2,4-dichloro-HCID 22993881HCID 22993881, compound

Product 1

HCID 22993886HCID 22993886, compoundYield 21.5%

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Procedure

Using the method of Example 17.4, 2-(3-chloro-5-pyridyloxy)-5-aminobenzotrifluoride (0.394 g) and 2,4-dichlorobenzenesulfonyl chloride (0.34 g ) were combined to provide, after flash chromatography and trituration with hexane/ether the title compound as a crystalline solid (0.146 g). mp 129-130° C.

Workup

  1. customto provide

Sources & evidence

ORD record
ord-5cc854a21611495896b8426291dbeb5d
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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