4-(Methylsulfanyl)benzene-1-sulfonyl chloride → HCID 9826187, compound

HRID 2116568Notes

Reaction equation

HRID 2116568 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[C:16]([F:19])([F:18])[F:17])[CH:7]=1.[CH3:20][S:21][C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1>CCCCCC.CCOCC>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][S:28]([C:25]3[CH:24]=[CH:23][C:22]([S:21][CH3:20])=[CH:27][CH:26]=3)(=[O:29])=[O:30])=[CH:11][C:10]=2[C:16]([F:17])([F:19])[F:18])[CH:7]=1

Participants

4

Reactant 2

HCID 111387314-(Methylsulfanyl)benzene-1-sulfonyl chlorideHCID 22993881HCID 22993881, compound

Product 1

HCID 9826187HCID 9826187, compoundYield 33.9%

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Procedure

Using the method of Example 17.4, 2-(3-chloro-5-pyridyloxy)-5-aminobenzotrifluoride (0.394 g) and 4-methylthiobenzenesulfonyl chloride (0.34 g ) [H. Burton, et al. J. Chem. Soc. 1948, 604-605] were combined to provide, after flash chromatography and trituration with hexane/ether, the title compound as crystals (0.22 g). mp 109.5-111° C.

Workup

  1. customto provide

Sources & evidence

ORD record
ord-0ca71d77799e42e8a40c3da8439c3d49
Source dataset
uspto-grants-2008_10
Patent number
US07439242B2

Reaction notes

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