AF 267B → HCID 11694209, compound

HRID 2116583Notes

Reaction equation

HRID 2116583 reaction equation
[CH2:1]([C@H:3]1[C:7](=[O:8])[NH:6][C:5]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:4]1)[CH3:2]>C1CCCCC1>[CH2:1]([C@@H:3]1[C:7](=[O:8])[NH:6][C:5]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:4]1)[CH3:2]

Participants

3

Reactant 1

HCID 10013505AF 267B

Product 1

HCID 11694209HCID 11694209, compound

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

The obtained (R)-2-mercaptobutyric acid was purified by distillation and then reacted with ammonium acetate and 1-methyl-4-piperidone in boiling cyclohexane. The crude reaction mixture was analyzed by GC on a chiral column and found to contain AF267A accompanied by a small (2-3%) amount of AF267B.

Workup

  1. distillationThe obtained (R)-2-mercaptobutyric acid was purified by distillation
  2. customreacted with ammonium acetate and 1-methyl-4-piperidone
  3. customThe crude reaction mixture

Sources & evidence

ORD record
ord-5d9a2257d1374c33bfcfb25fc22d07d0
Source dataset
uspto-grants-2008_10
Patent number
US07439251B2

Reaction notes

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