HCID 178512259, compound → HCID 178512358, compound

HRID 2116592Notes

Reaction equation

HRID 2116592 reaction equation
[C:1]([N:3]=[C:4](OC1C=CC=CC=1)[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]([C:15]2[S:16][CH:17]=[CH:18][C:19]=2[NH:20][CH2:21][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]=[CH:24][CH:23]=2)=[O:14])[CH:7]=1)#[N:2].C(N=C(OCC(F)(F)F)NC1C=CC=C(NC(C2SC=CC=2NCC2C3C(=CC=CC=3)N=CC=2)=O)C=1)#[N:40]>>[NH2:40][C:4]([NH:5][C:6]1[CH:7]=[C:8]([NH:12][C:13]([C:15]2[S:16][CH:17]=[CH:18][C:19]=2[NH:20][CH2:21][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]=[CH:24][CH:23]=2)=[O:14])[CH:9]=[CH:10][CH:11]=1)=[N:3][C:1]#[N:2]

Participants

3

Reactant 2

HCID 178512259HCID 178512259, compoundHCID 178512260HCID 178512260, compound

Product 1

HCID 178512358HCID 178512358, compound

Procedure

The following analogues were prepared using phenyl N′-cyano-N-{3-[({3-[(quinolin-4-ylmethyl)amino]thien-2-yl}carbonyl)amino]phenyl}imidocarbamate (EXAMPLE 1) or 2,2,2-Trifluoroethyl N′-Cyano-N-{3-[({3-[(quinolin-4-ylmethyl)amino]thien-2-yl}carbonyl)amino]phenyl}imidocarbamate (EXAMPLE 2) and the appropriate amine, according to the procedure described above for EXAMPLE 3.

Workup

  1. customThe following analogues were prepared

Sources & evidence

ORD record
ord-5521261eb1de4cb2a2532d7110676909
Source dataset
uspto-grants-2008_10
Patent number
US07439256B2

Reaction notes

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