反应详情

A solution of 0.6 g (3.5 mmol) of [(4-chloro-phenyl)oxy]ethylamine (Chim. Ther. 1973, 8, 259-270) and 1.3 g (5.8 mmol) of ethyl [(phenyloxy-carbonyl)oxy]acetate, prepared in Step 1.1., in 30 ml of toluene is heated at 60° C. overnight. It is evaporated to dryness and the product is purified by chromatography on silica gel, eluting with a 30/70 mixture of ethyl acetate and cyclohexane. This gives 0.7 g of oily product, containing ˜10% of cyclized oxazolidine dione product, used as it is in the following step.

1. customIt is evaporated to dryness
2. customthe product is purified by chromatography on silica gel
3. washeluting with a 30/70 mixture of ethyl acetate and cyclohexane
4. additionThis gives 0.7 g of oily product, containing ˜10% of cyclized oxazolidine dione product