Diethyl Ether → HCID 178459048, compound

Participants

Reaction Steps

To a solution of ethyl 2-mercapto-1,3-thiazole-4-carboxylate ((Ref: J. Am. Chem. Soc. 1935, 57, 1127), 0.694 g, 3.67 mmol) in Et2O (40 mL) at 0° C. was added EtMgBr (3 M in Et2O, 2.7 mL, 8.07 mmol). The reaction mixture was heated to reflux for 15 min, quenched with NH4Cl, extracted with 3 portions of Et2O, dried over MgSO4, filtered and concentrated in vacuo. The crude material was treated with more EtMgBr (3 M in Et2O, 6 mL, 18 mmol) at rt for 10 min, quenched, extracted and isolated in the same way. The residue was washed with Et2O and Et2O/hexane to afford the title compound.

Provenance & Evidence