Water → 2-(3,3,3-Trifluoropropyl)malononitrile

Participants

Reaction Steps

27.6 g of malononitrile was dissolved in 50 ml of N,N-dimethylformamide and 27.6 g of potassium carbonate was added thereto, followed by stirring for 1 hour at room temperature. To the solution was added the mixture of 17.7 g of 1-bromo-3,3,3-trifluoropropane and 20 ml of N,N-dimethylformamide and stirred for 1 hour. Then, the reaction mixture was poured into water and extracted with diethyl ether. The organic layer was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue obtained was subjected to silica gel column chromatography to give 11.3 g of 2-(3,3,3-trifluoropropyl)malononitrile.

Provenance & Evidence