HCID 68673838, compound → HCID 84070294, compound

HRID 2116695Notes

Reaction equation

HRID 2116695 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([C:10]([F:13])([F:12])[F:11])[C:3]=1[OH:14]>[O-2].[O-2].[Mn+4].ClCCl>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([C:10]([F:11])([F:12])[F:13])[C:3]=1[OH:14])[CH:8]=[O:9]

Participants

4

Reactant 1

HCID 68673838HCID 68673838, compound

Product 1

HCID 84070294HCID 84070294, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

30.0 g (345 mmol) manganese dioxide was added batchwise, with stirring, to a mixture of 5.90 g (26 mmol) 2-chloro-4-hydroxymethyl-6-trifluoromethyl-phenol and 100 ml dichloromethane and stirred for 2 hours at ambient temperature. The reaction mixture was suction filtered to remove the solid, the solution was evaporated down under reduced pressure and further reacted as the crude product.

Workup

  1. filtrationfiltered
  2. customto remove the solid
  3. customthe solution was evaporated down under reduced pressure
  4. customfurther reacted as the crude product

Sources & evidence

ORD record
ord-54eeca8fcfdc4307bd300f99b7651b58
Source dataset
uspto-grants-2008_10
Patent number
US07439237B2

Reaction notes

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