4-Morpholinopiperidine → HCID 58987932, compound

HRID 2116698Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[C:32]([C:35]([F:38])([F:37])[F:36])[C:33]=1[OH:34])[CH2:5][C@@H:6]([CH2:10][C:11](=[O:30])[N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:24][CH2:23][C:22]3[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=3[NH:20][C:19]2=[O:29])[CH2:14][CH2:13]1)[C:7]([OH:9])=O.[NH:39]1[CH2:44][CH2:43][CH:42]([N:45]2[CH2:50][CH2:49][O:48][CH2:47][CH2:46]2)[CH2:41][CH2:40]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[C:32]([C:35]([F:36])([F:37])[F:38])[C:33]=1[OH:34])[CH2:5][C@@H:6]([CH2:10][C:11]([N:12]1[CH2:13][CH2:14][CH:15]([N:18]2[CH2:24][CH2:23][C:22]3[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=3[NH:20][C:19]2=[O:29])[CH2:16][CH2:17]1)=[O:30])[C:7]([N:39]1[CH2:44][CH2:43][CH:42]([N:45]2[CH2:50][CH2:49][O:48][CH2:47][CH2:46]2)[CH2:41][CH2:40]1)=[O:9]

Participants

Reactant 2

HCID 7957244-Morpholinopiperidine

HCID 68673651HCID 68673651, compound

Product 1

HCID 58987932HCID 58987932, compound

Procedure

Prepared analogously to Example (1 g) from 70 mg (0.126 mmol) (S)-2-(3-chloro-4-hydroxy-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidin-1-yl]-butanoic acid and 22 mg (0.130 mmol) 4-piperidin-4-yl-morpholine.

Sources & evidence

ORD record: ord-37b1a7988d784e0da413ffcc5e023cdf
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07439237B2

Reaction notes

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