Benzyl chloroformate → HCID 68948944, compound

Participants

Reaction Conditions

Reaction Steps

[6-(tert-Butyl-dimethyl-silanyloxy)-1H-indol-2-yl]-methylamine (0.70 g, 1.01 mmol) is dissolved in DCM (10 ml), cooled to 0° C. DIEA (0.35 ml, 2.02 mmol) and Cbz-Cl (0.17 g, 1.01 mmol) are added. The mixture is stirred for 1 hour at room temperature. The reaction mixture is concentrated and the residue is purified by column chromatography (10% ethyl acetate in hexanes) to provide [6-(tert-Butyl-dimethyl-silanyloxy)-1H-indol-2-ylmethyl]-carbamic acid benzyl ester.

Provenance & Evidence