HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl 2-bromo-3-(3-methyl-2-buten-1-yl)-5-formyl-3H-imidazole-4-carboxylate → ethyl 2-bromo-3-(but-2-ynyl)-5-formyl-3H-imidazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl 2-bromo-3-(3-methyl-2-buten-1-yl)-5-formyl-3H-imidazole-4-carboxylate | HCID 11580300 | — |
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Reactant | diethyl 2-bromo-1-(but-2-ynyl)-1H-imidazole-4,5-dicarboxylate | HCID 59815044 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | ethyl 2-bromo-3-(but-2-ynyl)-5-formyl-3H-imidazole-4-carboxylate | HCID 11522264 | — |
Reaction Steps
Prepared analogously to 1c from 20.00 g (58.28 mmol) diethyl 2-bromo-1-(but-2-ynyl)-1H-imidazole-4,5-dicarboxylate with 70 ml (70 mmol) diisobutylaluminium hydride in 300 ml of tetrahydrofuran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07439370B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-1805532357b045449f77d2bffd3a11ea |
| Source note | uspto-grants-2008_10 |