Ethanol → 6-[[[1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]pyrrolidin-3-yl]methylamino]methyl]-4H-pyrido[3,2-b][1,4]thiazin-3-one

HRID 211683Notes

Reaction equation

HRID 211683 reaction equation
[BH4-:35].[CH3:1][O:2][c:3]1[n:4][c:5]2[c:6]([CH2:13][CH2:14][N:15]3[CH2:16][CH:17]([CH2:20][NH2:21])[CH2:18][CH2:19]3)[cH:7][cH:8][n:9][c:10]2[cH:11][cH:12]1.[CH3:40][CH2:41][OH:42].[Cl:37][CH2:38][Cl:39].[Na+:36].[O:22]=[C:23]1[CH2:24][S:25][c:26]2[c:27]([n:29][c:30]([CH:33]=[O:34])[cH:31][cH:32]2)[NH:28]1>>[CH3:1][O:2][c:3]1[n:4][c:5]2[c:6]([CH2:13][CH2:14][N:15]3[CH2:16][CH:17]([CH2:20][NH:21][CH2:33][c:30]4[n:29][c:27]5[c:26]([cH:32][cH:31]4)[S:25][CH2:24][C:23](=[O:22])[NH:28]5)[CH2:18][CH2:19]3)[cH:7][cH:8][n:9][c:10]2[cH:11][cH:12]1

Participants

7

Reactant 6

HCID 702EthanolHCID 923Sodium ionHCID 6344DichloromethaneHCID 28123BorohydrideHCID 115935913-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehydeHCID 72493302HCID 72493302, compound

Product 1

HCID 730461736-[[[1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]pyrrolidin-3-yl]methylamino]methyl]-4H-pyrido[3,2-b][1,4]thiazin-3-one

Sources & evidence

ORD record
ord-1116b16d4234488898ee1aa08fbd204d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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