Sodium Hydroxide → HCID 72816966, compound

Participants

Reaction Steps

In a manner similar to that of Example 1.g, by reaction of 120 mg (0.3 mmol) of methyl 4-[2-(3-tert-butyl-4-diethylaminophenyl)-2-hydroxyiminoethoxy]-2-hydroxybenzoate with 46 mg (1.4 mmol) of powdered sodium hydroxide. The final product is then recrystallized from a heptane/ethyl ether system. A white crystalline solid is obtained (m.p.=210° C., m=60 mg, yield=48%); (1H NMR (DMSO): 0.96-1.00 (t, 6H); 1.38 (s, 9H); 2.7-3 (m, 4H); 5.26 (s, 2H); 6.46-6.49 (dd, J=6.4 Hz, J′=2.4 Hz, 1H); 6.55 (d, J=2.4 Hz, 1H); 7.26-7.28 (d, J=8.3 Hz, 1H); 7.46-7.48 (dd, J=6.2 Hz, J′=2.03 Hz,1H); 7.65-7.67 (d, J=8.8 Hz, 1H); 7.69 (d, J=2.03 Hz, 1H); 11.9 (s, 1H); 13-14 (s, 1H)).

Provenance & Evidence