Sodium Hydroxide → HCID 69292867, compound

Participants

Reaction Steps

In a manner similar to that of Example 1.h, by reaction of 210 mg (0.5 mmol) of methyl 4-[2-(3-tert-butyl-4-pyrrolidin-1-ylphenyl)-2-hydroxyiminoethoxy]benzoate with 100 mg (2.5 mmol) of sodium hydroxide. A white solid is obtained after recrystallization (m.p.=235° C., m=44 mg, yield=22%); (1H NMR (DMSO): 1.35 (s, 9H); 1.86 (s, 4H); 2.89 (s, 4H); 5.29 (s, 2H); 7.04-7.06 (d, J=7.65 Hz, 2H); 7.40-7.42 (d, J=7.4 Hz, 1H); 7.49-7.51 (d, J=7.4 Hz, 1H); 7.65 (s, 1H); 7.86-7.88 (d, J=7.4 Hz, 2H); 11.9 (s, 1H); 12.6 (s, 1H)).

Provenance & Evidence