Sodium Hydroxide → HCID 72953816, compound

Participants

Reaction Steps

In a manner similar to that of Example 1.g, by reaction of 193 mg (0.45 mmol) of methyl 4-[2-(3-tert-butyl4-pyrrolidin-1-ylphenyl)-2-hydroxyiminoethoxy]-2-hydroxybenzoate with 90 mg (2.3 mmol) of powdered sodium hydroxide. The final product is then recrystallized from a heptane/ethyl ether system. A beige-colored crystalline solid is obtained (m.p.=234° C., m=25 mg, yield=13%); (1H NMR (DMSO): 1.35 (s, 9H); 1.86 (s, 4H); 2.89 (s, 4H); 5.26 (s, 2H); 6.46-6.49 (d, J=8.6 Hz, 1H); 6.5 (s, 1 H); 7.40-7.42 (d, J=8.2 Hz, 1H); 7.49-7.51 (d, J=7.9 Hz, 1H); 7.66-7.68 (d, J=8.5 Hz, 2H); 11.9 (s, 1H)).

Provenance & Evidence