Morpholine → HCID 69290840, compound

Participants

Reaction Steps

In a manner similar to that of Example 5.h, by reaction of 380 mg (0.8 mmol) of allyl 4-{2-[4-(acetylethylamino)-3-tert-butylphenyl]-2-hydroxyiminoethoxy}-2-hydroxybenzoate with 48 mg (0.04 mmol) of tetrakis(triphenylphosphine)palladium and 73 μl (0.8 mmol) of morpholine. A white powder is obtained (m.p.=199° C., m=200 mg, yield=59%); (1H NMR (DMSO): 1.05-1.08 (t, 3H); 1.29 (s, 9H); 1.64 (s, 3H); 2.7-2.8 (m, 1H); 4.1-4.2 (m, 1H); 5.34 (s, 2H); 6.44-6.47 (dd, J=6.8 Hz, J′=2.2 Hz, 1H); 6.53 (d, J=2 Hz, 1H); 7.07-7.09 (d, J=8.2 Hz, 1H); 7.51-7.53 (dd, J=6 Hz, J′=1.86Hz, 1H); 7.65-7.67 (d, J=8.8 Hz, 1H); 7.86 (d, J=1.78Hz, 1H); 12.2 (s, 1H)).

Provenance & Evidence