Isobutyryl bromide → HCID 10300933, compound

HRID 2116876Notes

Reaction equation

[Br-].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][C:4]=1[C@@H:11]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:12][CH2:13][N+:14]([CH:19]([CH3:21])[CH3:20])([CH:16]([CH3:18])[CH3:17])[CH3:15].[C:28]([Br:33])(=[O:32])[CH:29]([CH3:31])[CH3:30]>>[Br-:33].[C:28]([O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[CH:5][C:4]=1[C@@H:11]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:12][CH2:13][N+:14]([CH:19]([CH3:20])[CH3:21])([CH:16]([CH3:17])[CH3:18])[CH3:15])(=[O:32])[CH:29]([CH3:31])[CH3:30]

Participants

Reactant 2

HCID 520309Isobutyryl bromide

HCID 69134111HCID 69134111, compound

Product 1

HCID 10300933HCID 10300933, compound

Procedure

(3R)-3-[2-hydroxy-5-(hydroxymethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide is acylated with isobutyryl bromide to give the title compound.

Sources & evidence

ORD record: ord-5738a961b12341c2bc9902664000b9a4
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07439397B2

Reaction notes

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