Hydrochloric Acid → Atomoxetine Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Two grams (0.00491 mol) of atomoxetine (S)-(+)-mandelate was mixed at room temperature with 10 ml of toluene and 1 ml of MeOH and under stirring were heated at 60° C. Keeping the temperature at 60° C. by means of oil bath heating, 0.58 g of aqueous (37%) hydrogen chloride was dropped into the obtained solution. The solution was cooled and at 20-25° C. a solid crystallized. The slurry was stirred for 1 hour at 0° C., then the solid was collected by filtration, washed with toluene and dried under vacuum at 45° C. for 5 hours.

Provenance & Evidence