Hydrochloric Acid → Atomoxetine Hydrochloride

Participants

Reaction Steps

Atomoxetine (S)-(+)-Mandelate (5.17 g, 0.01267 mol) was mixed at room temperature with 25.5 ml of n-butyl acetate and 0.6 ml of toluene under stirring. Keeping the temperature between about 18° C. and about 20° C. by means of water-ice bath cooling, 1.4 g of aqueous (36.4% w/w) hydrogen chloride was added into the obtained slurry. The slurry was stirred for 1 hour at room temperature. The solid was collected by filtration, washed with 6 ml of n-butyl acetate and dried in vacuo at 65° C.

Provenance & Evidence