Hydrochloric Acid → Atomoxetine Hydrochloride

Participants

Reaction Steps

Atomoxetine (S)-(+)-mandelate (5.17 g, 0.01267 mol) was mixed at about 50° C. with 25.5 ml of n-butyl acetate and 0.6 ml of toluene under stirring. Keeping the temperature at 50° C. by means of oil bath heating, 1.4 g of aqueous (36.4% w/w) hydrogen chloride was added into the obtained slurry. The slurry that formed was cooled at room temperature and stirred for 1 hour. The solid was collected by filtration, washed with 6 ml of n-butyl acetate and dried in vacuo at 45° C.

Provenance & Evidence