2,3-Dichloropyridine → HCID 86760733, compound

Participants

Reaction Steps

A mixture of (2R)-1-(4-(3,4-difluorophenyl)-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-2-methylpiperazine from step (d) above (150 mg, 0.355 mmol), 2,3-dichloropyridine (104 mg, 0.71 mmol, Lancaster), and sodium bicarbonate (89 mg, 1.1 mmol, Mallinckrodt) in NMP (1.2 mL) was reacted under the condition of Example 12(a) to give the title compound as a tan solid. MS (ESI, positive ion) m/z: 534 (M+1).

Provenance & Evidence