Lithium Hydroxide → HCID 178456369, compound

Participants

Reaction Steps

A solution of methyl 5-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate from step (d) above (500. mg, 0.794 mmol) in THF:H2O (5:1) was added LiOH (29 mg, 1.19 mmol, Aldrich) at 0° C. The mixture was stirred at RT for 16 h and the solvents were removed. The residue was dissolved in H2O (20 mL) and the aqueous solution was adjusted to pH ˜7. Then, the solvents were removed and the residue was purified on silica gel using ISCO Combiflash® system with EtOAc/Hexanes (1:4) as the eluant to give the title compound as a white solid. MS (ESI, positive ion) m/z: 616 (M+1).

Provenance & Evidence