2-Chloro-3-(trifluoromethyl)pyridine → HCID 178506119, compound

HRID 2116907Notes

Reaction equation

HRID 2116907 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([C:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH:22]=2)[NH:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1.Cl[C:24]1[C:29]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:27]=[CH:26][N:25]=1>>[Cl:1][C:2]1[N:3]=[C:4]([C:17]2[CH2:18][CH2:19][N:20]([C:24]3[C:29]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:27]=[CH:26][N:25]=3)[CH2:21][CH:22]=2)[NH:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:14])([F:15])[F:16])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 178506120HCID 178506120, compound

Product 1

HCID 178506119HCID 178506119, compound

Procedure

4-[4-Chloro-5-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-1,2,3,6-tetrahydropyridine from step (b) above reacted with 2-chloro-3-trifluoromethyl-pyridine (251 mg, 1.39 mmol, TCI America) under the conditions of Example 22(d) to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 473 (M+1).

Sources & evidence

ORD record
ord-bf317983acca421186cb3f2fca09a292
Source dataset
uspto-grants-2008_10
Patent number
US07439360B2

Reaction notes

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