2-Chloro-3-(trifluoromethyl)pyridine → 2-(4-(4,5-Bis-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-5,6-dihydropyridin-1(2H)-yl)-3-(trifluoromethyl)pyridine

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-3-(trifluoromethyl)pyridine	HCID 589833	—
Reactant	4-[4,5-Bis-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-1,2,3,6-tetrahydropyridine	HCID 58625818	—
Product	2-(4-(4,5-Bis-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-5,6-dihydropyridin-1(2H)-yl)-3-(trifluoromethyl)pyridine	HCID 11664273	—

Reaction Steps

4-[4,5-Bis-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-1,2,3,6-tetrahydropyridine from step (b) above reacted with 2-chloro-3-trifluoromethyl-pyridine (352 mg, 1.95 mmol, TCI America) under the condition of Example 22(d) to give the title compound as a light-yellow solid. MS (ESI, positive ion) m/z: 583 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07439360B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-7a47e49fe73340bfa085bb8b3b2f028d
Source note	uspto-grants-2008_10