Diisopropylethylamine → HCID 178448475, compound

Participants

Reaction Steps

A mixture of 5-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-imidazole-4-carboxylic acid from step (d) above (50. mg, 0.103 mmol), (1-isobutylpiperidin-2-yl)methanamine (26 mg, 0.15 mmol, Example 29(c)), benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (68 mg, 0.154 mmol, Aldrich), and DIEA (0.053 mL, 0.975 mmol, Aldrich) in DCM (0.6 mL) reacted under the condition of Example 16(f) to give the title compound as a white solid. MS (ESI, positive ion) m/z: 638 (M+1).

Provenance & Evidence