Diisopropylethylamine → HCID 178522965, compound

Participants

Reaction Steps

A mixture of 5-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (300. mg, 0.487 mmol, Example 16(e)), tert-butyl 2-(aminomethyl)piperidine-1-carboxylate (209 mg, 0.974 mmol, Astatech), benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (323 mg, 0.731 mmol, Aldrich), and DIEA (0.25 mL, 0.98 mmol, Aldrich) in DCM (3 mL) reacted under the condition of Example 16(f) to give the title compound as a light purple solid. MS (ESI, positive ion) m/z: 812 (M+1).

Provenance & Evidence