Diisopropylethylamine → HCID 178462524, compound

Participants

Reaction Steps

A mixture of 5-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylic acid (200. mg, 0.325 mmol, Example (16e)), (1-ethylpyrrolidin-2-yl)methanamine (83 mg, 0.65 mmol, Acros), benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (216 mg, 0.487 mmol, Aldrich), and DIEA (0.170 mL, 0.975 mmol, Aldrich) in DCM (2 mL) reacted under the condition of Example 16(f) and Example 16(g) to give the title compound as a light yellow solid. MS (ESI, positive ion) m/z: 596 (M+1).

Provenance & Evidence