N,N-Dimethyl-1,3-propanediamine → HCID 491195, compound

HRID 2117018Notes

Reaction equation

HRID 2117018 reaction equation
CN(C)C[CH2:4][NH:5][C:6]([C@@H:8]([NH:20][C:21]([C:23]1[CH:42]=[CH:41][C:26]2[N:27]([CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:28]([C:30]3[CH:34]=[CH:33][O:32][CH:31]=3)=[N:29][C:25]=2[CH:24]=1)=[O:22])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=2)[NH:12][CH:11]=1)=[O:7].[CH3:44][N:45]([CH2:47][CH2:48]CN)[CH3:46]>>[CH3:44][N:45]([CH3:46])[CH2:47][CH2:48][CH2:4][NH:5][C:6]([C@@H:8]([NH:20][C:21]([C:23]1[CH:42]=[CH:41][C:26]2[N:27]([CH:35]3[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]3)[C:28]([C:30]3[CH:34]=[CH:33][O:32][CH:31]=3)=[N:29][C:25]=2[CH:24]=1)=[O:22])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=2)[NH:12][CH:11]=1)=[O:7]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 491192HCID 491192, compound

Product 1

HCID 491195HCID 491195, compound

Procedure

The carboxylic acid of example 133 was coupled to dimethylaminopropylamine under standard TBTU conditions to yield the title compound of example 136.

Sources & evidence

ORD record
ord-1c66614a72ff4b0b8eaacd4db88166c9
Source dataset
uspto-grants-2008_10
Patent number
US07439258B2

Reaction notes

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