HCID 59814732, compound → HCID 59814668, compound

HRID 2117052Notes

Reaction equation

HRID 2117052 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:18]3[CH2:24][CH:23]4[N:25](C)[CH:20]([CH2:21][CH2:22]4)[CH2:19]3)[C:7]3[C:12]([S:13][C:14]=2[CH:15]=1)=[C:11]([O:16][CH3:17])[CH:10]=[CH:9][CH:8]=3.BrC1C=CC2N(C3CC4N(C)C(CC4)C3)C3C(SC=2C=1)=CC=CC=3>>[CH:23]12[NH:25][CH:20]([CH2:21][CH2:22]1)[CH2:19][CH:18]([N:6]1[C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:15][C:14]=3[S:13][C:12]3[C:7]1=[CH:8][CH:9]=[CH:10][C:11]=3[O:16][CH3:17])[CH2:24]2

Participants

3

Reactant 2

HCID 59814732HCID 59814732, compound2×HCID 59814737HCID 59814737, compound

Product 1

HCID 59814668HCID 59814668, compound

Procedure

Using an adaptation of the method described in Procedure 21, substituting 3-bromo-6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3cc for 3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3i, the title compound 10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-6-methoxy-10H-phenothiazine, 4cc was obtained a mixture of endo and exo isomers.

Sources & evidence

ORD record
ord-6a8fdb7d19d94a8a80f5db41a36e0eef
Source dataset
uspto-grants-2008_10
Patent number
US07439239B2

Reaction notes

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